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Review Article

天然产物棉酚及其衍生物在精准癌症医学中的应用

卷 26, 期 10, 2019

页: [1849 - 1873] 页: 25

弟呕挨: 10.2174/0929867324666170523123655

价格: $65

摘要

棉酚是从棉花的种子，根和茎中提取的天然产物，最初用作男性避孕药，但随后被研究作为一种新型抗肿瘤剂。该综述描述了棉酚及其衍生物作为新型抗肿瘤剂的现状，并通过定量和结构分析介绍了它们的制备和特性，尤其是一些棉酚Schiff碱。棉酚及其衍生物的主要吸引靶位点是含有抗凋亡蛋白Bcl-2和Bcl-XL的Bcl-2家族蛋白。棉酚类似物的分子机制不仅涉及细胞凋亡，还涉及自噬，细胞周期停滞和其他异常细胞现象。棉酚及其衍生物在体外和体内对不同的癌症类型发挥抗肿瘤作用，并显示出与其他化学和放射治疗相比的协同作用。此外，已经设计了几种纳米载体来装载棉酚或其衍生物，以扩大其应用范围并评估它们与其他抗肿瘤剂的组合效果。该综述可作为合理应用棉酚类似物作为抗肿瘤剂的参考。

关键词: 抗肿瘤作用，细胞凋亡，自噬，Bcl-2家族蛋白，棉酚，纳米载体，协同作用。

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