Physical Exercise and ACE2-Angiotensin-(1-7)-Mas Receptor Axis of the Renin Angiotensin System

Title:Physical Exercise and ACE2-Angiotensin-(1-7)-Mas Receptor Axis of the Renin Angiotensin System

Volume: 24 Issue: 9

Author(s): Albena Nunes-Silva, Guilherme Carvalho Rocha, Daniel Massote Magalhaes, Lucas Neves Vaz, Marcelo Henrique Salviano de Faria and Ana Cristina Simoes e Silva*

Affiliation:

• Laboratorio Interdisciplinar de Investigacao Medica, Avenida Alfredo Balena, 190, 2o andar, sala 281, Belo Horizonte, MG,Brazil

Keywords: Physical exercise, physical training, renin angiotensin system, ACE2, angiotensin-(1-7), Mas receptor.

Abstract: Background: Many physiological responses of the Renin Angiotensin System (RAS) are associated with two opposite pathways: (1) a classical one formed by angiotensin-converting enzyme (ACE), Angiotensin II (Ang II) and Angiotensin type 1 (AT1) receptor, which is associated to vasoconstriction, cell proliferation, organ hypertrophy, sodium retention and aldosterone release and (2) a counter-regulatory or vasodilator pathway comprising angiotensin-converting enzyme 2 (ACE2), Angiotensin-(1-7) [Ang-(1-7)] and Mas receptor, which is involved in vasodilation, antiproliferation, anti-hypertrophy, cardioprotective and renoprotective actions.

Objective: This review aimed to bring up-to-date on the interactions between physical exercise and the vasodilator axis of the RAS (ACE2-Ang-(1-7)-Mas receptor axis). We also investigated the relation of acute and chronic exercise with blood pressure regulation and components of the vasodilator axis of the RAS.

Methods: We searched studies with animal models and humans in PUBMED, LILACS and IBECS. Results: Experimental studies showed that physical training can stimulate ACE2-Ang-(1-7)-Mas receptor axis in parallel with the inhibition of ACE-Ang II-AT1 receptor pathway. However, up to now, the interaction between the counter-regulatory RAS axis and physical training is not investigated in humans.

Conclusion: The activation of ACE2-Ang-(1-7)-Mas receptor axis may have a role in the beneficial effects of physical training in experimental models. Further studies with humans are necessary.

Cite this article as:

Nunes-Silva Albena , Rocha Carvalho Guilherme , Magalhaes Massote Daniel, Vaz Neves Lucas , Salviano de Faria Henrique Marcelo and Simoes e Silva Cristina Ana *, Physical Exercise and ACE2-Angiotensin-(1-7)-Mas Receptor Axis of the Renin Angiotensin System, Protein & Peptide Letters 2017; 24 (9) . https://dx.doi.org/10.2174/0929866524666170728151401