Abstract
Genomics and proteomics have unveiled a plethora of protein-protein interactions that may control cellular processes involved in disease development. Many of these interactions involve non-traditional candidate targets (i.e., neither enzymes nor cell surface receptors / channels). To date, non-traditional targets have largely been ignored by the pharmaceutical industry or have failed to lead to drugs. This review focuses on the use of transdominant genetically encoded agents and specialized small-molecule drugs to explore this void.
Keywords: transdominant genetics, reverse genetics, protein-protein interaction, non-traditional drug target
Current Gene Therapy
Title: Non-Traditional Drug Targets: High Risk, High Reward
Volume: 3 Issue: 5
Author(s): Tanya Sandrock and Alexander Kamb
Affiliation:
Keywords: transdominant genetics, reverse genetics, protein-protein interaction, non-traditional drug target
Abstract: Genomics and proteomics have unveiled a plethora of protein-protein interactions that may control cellular processes involved in disease development. Many of these interactions involve non-traditional candidate targets (i.e., neither enzymes nor cell surface receptors / channels). To date, non-traditional targets have largely been ignored by the pharmaceutical industry or have failed to lead to drugs. This review focuses on the use of transdominant genetically encoded agents and specialized small-molecule drugs to explore this void.
Export Options
About this article
Cite this article as:
Sandrock Tanya and Kamb Alexander, Non-Traditional Drug Targets: High Risk, High Reward, Current Gene Therapy 2003; 3 (5) . https://dx.doi.org/10.2174/1566523034578212
DOI https://dx.doi.org/10.2174/1566523034578212 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
Call for Papers in Thematic Issues
Programmed Cell Death Genes in Oncology: Pioneering Therapeutic and Diagnostic Frontiers (BMS-CGT-2024-HT-45)
Programmed Cell Death (PCD) is recognized as a pivotal biological mechanism with far-reaching effects in the realm of cancer therapy. This complex process encompasses a variety of cell death modalities, including apoptosis, autophagic cell death, pyroptosis, and ferroptosis, each of which contributes to the intricate landscape of cancer development and ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Current Status of Antimalarial Drug Research with Special Reference to Application of QSAR Models
Combinatorial Chemistry & High Throughput Screening Mannosylated Solid Lipid Nanocarriers of Chrysin to Target Gastric Cancer: Optimization and Cell Line Study
Current Drug Delivery Enhancing the Delivery of Anti Retroviral Drug “Saquinavir” Across the Blood Brain Barrier Using Nanoparticles
Current HIV Research Structure-Based Drug Design, Molecular Dynamics and ADME/Tox to Investigate Protein Kinase Anti-Cancer Agents
Current Bioactive Compounds Coronary Risk Factors in the Elderly: Their Interactions and Treatment
Current Pharmaceutical Design Production and Characterization of a Novel Bioflocculant from Klebsiella sp.
Current Biotechnology The Potent Inhibitory Effect of β-D-Mannuronic Acid (M2000) as a Novel NSAID with Immunosuppressive Property on Anti-Cyclic Citrullinated Peptide Antibodies, Rheumatoid Factor and Anti-dsDNA Antibodies in Patients with Rheumatoid Arthritis
Current Drug Discovery Technologies Applications of Molecularly Imprinted Polymers for Isolation of Estrogens from Environmental Water Samples
Current Analytical Chemistry QSPR in Oral Bioavailability: Specificity or Integrality?
Mini-Reviews in Medicinal Chemistry The Role of Atelocollagen-Based Cell Transfection Array in High- Throughput Screening of Gene Functions and in Drug Discovery
Current Drug Discovery Technologies Understanding the Cardiovascular Actions of Soy Isoflavones: Potential Novel Targets for Antihypertensive Drug Development
Cardiovascular & Hematological Disorders-Drug Targets Epidemics and Peptide Vaccine Response: A Brief Review
Current Topics in Medicinal Chemistry From Surface to Nuclear Receptors: The Endocannabinoid Family Extends its Assets
Current Medicinal Chemistry Environmental Contaminants Perturb Fragile Protein Assemblies and Inhibit Normal Protein Function
Current Chemical Biology Quantum Dot Nanocrystals and Supramolecular Lanthanide Complexes -Energy Transfer Systems for Sensitive In Vitro Diagnostics and High Throughput Screening in Chemical Biology
Current Chemical Biology Towards A Superior Streptokinase for Fibrinolytic Therapy of Vascular Thrombosis
Cardiovascular & Hematological Agents in Medicinal Chemistry HIV-1 Matrix Protein p17 and its Receptors
Current Drug Targets Synthesis and Cytotoxic Activity of 4-Aryl-4H-chromeno[4,3-d] [1,2,3] selenadiazoles
Letters in Drug Design & Discovery Pharmacokinetics of Polymeric Micelles for Cancer Treatment
Current Drug Metabolism Biomarkers of Oxidative Stress in the Assessment of Enantioselective Toxicity of Chiral Pesticides
Current Protein & Peptide Science