摘要
常见的脑小血管疾病(cSVD)异常是一种常见的神经放射学发现,特别是在老年人中。它们与广泛的临床谱有关,导致残疾增加,全球功能结果受损和生活质量下降。与年龄和高血压以及其他常见血管危险因素(包括糖尿病,血脂异常,吸烟,低维生素B12水平和高半胱氨酸血症)有密切关系。虽然这些流行病学协会提出了系统性的参与,但是遗传机制仍不清楚。本文综述了内皮功能障碍和氧化应激在导致cSVD的致病级联中的潜在作用。我们强调了这些途径的中心作用,并提出量化大脑(和非唯一)“内皮损伤和氧化负荷”及其临床表现的重要性,可能导致更好地确定血管风险程度。此外,了解潜在的致病机制可以使我们减缓血管损伤的进展,从而防止由于重复的微血管损伤造成的残疾。
关键词: 小血管疾病,脑白质疏松症,白质高强度,氧化应激,内皮细胞病变,生物标志物,循环综合征
Current Molecular Medicine
Title:Endothelium and Oxidative Stress: The Pandora's Box of Cerebral (and Non-Only) Small Vessel Disease?
Volume: 17 Issue: 3
关键词: 小血管疾病,脑白质疏松症,白质高强度,氧化应激,内皮细胞病变,生物标志物,循环综合征
摘要: Common cerebral small vessel disease (cSVD) abnormalities are a common neuroradiological finding, especially in the elderly. They are associated with a wide clinical spectrum that leads to an increasing disability, impaired global function outcome and a reduced quality of life. A strong association is demonstrated with age and hypertension and other common vascular risk factors, including diabetes mellitus, dyslipoproteinemia, smoking, low vitamin B12 level, and hyperomocysteinemia. Although these epidemiological associations suggest a systemic involvement, etiopathogenetic mechanisms remain unclear. This review focuses on the potential role of endothelial dysfunction and oxidative stress in the pathogenic cascade leading to cSVD. We stressed on the central role of those pathways, and suggest the importance of quantifying the cerebral (and non-only) “endotheliopathic and oxidative load” and its clinical presentation that could lead to a better determination of vascular risk degree. In addition, understanding underlying pathogenic mechanisms could allow us to slow down the progression of vascular damage and, therefore, prevent the disability due to reiterated microvascular damage.
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Cite this article as:
Endothelium and Oxidative Stress: The Pandora's Box of Cerebral (and Non-Only) Small Vessel Disease?, Current Molecular Medicine 2017; 17 (3) . https://dx.doi.org/10.2174/1566524017666170822114739
DOI https://dx.doi.org/10.2174/1566524017666170822114739 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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