摘要
男性的认知功能和睾酮水平随年龄增长而下降。低睾酮水平与男性阿尔茨海默病和轻度认知障碍的风险较高有关。对于这种关系是否随意存在持续的争论。本文旨在总结目前关于老年男性睾酮水平与认知功能之间关系的证据。睾酮,雄激素受体及其反应基因的存在表明睾酮在中枢神经系统中具有生物学功能。身体将睾酮转化为雌激素的能力表明睾酮的部分作用可以由雌激素介导。观察性研究普遍表明,低内源性睾酮水平与健康老年男性认知能力差相关。睾酮替代对正常和性腺功能减退的老年男性的某些认知域产生积极作用。总之,睾酮可能影响老年男性的认知功能,其替代可能被认为是男性认知障碍和睾酮缺乏。
关键词: 衰老,阿尔茨海默病,睾酮,脑,性腺机能减退,认知能力。
Current Drug Targets
Title:A Review on the Effects of Testosterone Supplementation in Hypogonadal Men with Cognitive Impairment
Volume: 19 Issue: 8
关键词: 衰老,阿尔茨海默病,睾酮,脑,性腺机能减退,认知能力。
摘要: Cognitive function and testosterone level of men decline concurrently with age. Low testosterone levels are associated with higher risk of Alzheimer’s disease and mild cognitive impairment in men. There are continuous debates on whether this relationship is casual. This paper aims to summarize the current evidence on the association between testosterone level and cognitive function in elderly men. The presence of testosterone, androgen receptor and its responsive genes indicates that testosterone has biological functions in the central nervous system. The ability of the body to convert testosterone into estrogen suggests that part of the actions of testosterone could be mediated by estrogen. Observational studies generally showed that low endogenous testosterone levels were associated with poor cognitive performance in healthy elderly men. Testosterone substitution exerted positive effects on certain cognitive domains in normal and hypogonadal elderly men. In conclusion, testosterone may influence cognitive function in elderly men and its substitution may be considered in men with cognitive impairment and testosterone deficiency.
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A Review on the Effects of Testosterone Supplementation in Hypogonadal Men with Cognitive Impairment, Current Drug Targets 2018; 19 (8) . https://dx.doi.org/10.2174/1389450118666170913162739
DOI https://dx.doi.org/10.2174/1389450118666170913162739 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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