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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Ionotropic Glutamate Receptor Biology: Effect on Synaptic Connectivity and Function in Neurological Disease

Author(s): G. N. Barnes and J. T. Slevin

Volume 10, Issue 20, 2003

Page: [2059 - 2072] Pages: 14

DOI: 10.2174/0929867033456800

Price: $65

Abstract

Glutamate receptor signaling is essential to normal synaptic function in the central nervous system. The major ionotropic glutamate receptors (AMPA, Kainic, and NMDA) have different synaptic functions depending upon cellular and subcellular localization, subunit composition, and second messenger systems linked to the receptors. In this review, we examine major advances in glutamate receptor biology whose physiology plays a central role in neurologic disease such as epilepsy and stroke. A key feature of glutamate receptor activation in neurologic disease is the downstream effects on cell survival, genetic expression of axon guidance cues, synaptic connectivity / formation of networks, and neuronal excitability. Identification of therapeutic pharmacologic targets and development of antagonists specific to the disease process remain central themes in epilepsy and stroke research.

Keywords: glutamate, epilepsy, sprouting, kainic acid, kindling

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