摘要
背景:睾丸生殖细胞肿瘤(TGCT)是20至34岁年轻男性中最常见的实体恶性肿瘤,其发病率在过去几十年中显着增加。 TGCT可细分为精原细胞瘤和非小细胞瘤生殖细胞瘤(NSGCT),其中包括卵黄囊肿瘤,绒毛膜癌,胚胎细胞癌和畸胎瘤。精原细胞瘤和NSGCT在治疗,预后方面存在显着差异,并且都显示原始生殖细胞(PGCs)的特征。 方法:我从同行评议的研究文献中搜索书目数据。 结果:70篇论文被纳入微型评论中,显示大量新生物标志物具有进一步的优势来区分不同的组织类型,并且可以代表抗癌策略的有用的新型分子靶标。 结论:对TGCT发病机制的深入了解不仅可以显着改善我们对干细胞和肿瘤发生的认识,而且可以显着提高肿瘤治疗的选择性。
关键词: 睾丸生殖细胞肿瘤,精原细胞瘤,Aurora B,GPR30,PATZ1,HMGA。
Current Medicinal Chemistry
Title:Recent Advances in New Discovered Molecular Targets in Testicular Germ Cell Tumors
Volume: 25 Issue: 5
关键词: 睾丸生殖细胞肿瘤,精原细胞瘤,Aurora B,GPR30,PATZ1,HMGA。
摘要: Background: Testicular germ cell tumor (TGCT) is the most common solid malignancy occurring in young men between 20 and 34 years of age, and its incidence has increased significantly over the last decades. TGCTs can be subdivided into seminoma and nonseminoma germ cell tumors (NSGCTs), which includes yolk sac tumor, choriocarcinoma, embryonal cell carcinoma, and teratoma. Seminomas and NSGCTs present significant differences in therapy, prognosis, and both show characteristics of the Primordial Germ Cells (PGCs).
Methods: I undertook a search of bibliographic data from peer-reviewed research literature.
Results: Seventy papers were included in the mini-review showing that a large number of new biomarkers have given further advantages to discriminate the different histotypes and could represent useful novel molecular targets for anticancer strategies.
Conclusion: A deeper understanding of the pathogenesis of TGCTs is likely to significantly improve not only our knowledge on stem cells and oncogenesis but also the disease management with more selective tumor treatment.
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Cite this article as:
Recent Advances in New Discovered Molecular Targets in Testicular Germ Cell Tumors, Current Medicinal Chemistry 2018; 25 (5) . https://dx.doi.org/10.2174/0929867324666171003115807
DOI https://dx.doi.org/10.2174/0929867324666171003115807 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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