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Review Article

现代代谢性疾病脂质分析的质谱方法进展

卷 26, 期 1, 2019

页: [60 - 103] 页: 44

弟呕挨: 10.2174/0929867324666171003121127

价格: $65

摘要

背景：肥胖、胰岛素抵抗、糖尿病和代谢综合征与脂质改变有关，它们影响长期心血管疾病的风险。一个可靠的分析仪器来检测类脂的成分或结构的变化，以及能够将特定类脂组的变化与特定疾病及其进展联系起来的工具，一直是缺乏的。脂质体是一个新的医学领域，在研究和鉴定脂质和脂质代谢产物的基础上存在于人体。脂质沉积的主要目的是寻找不同疾病的新的生物标志物，主要是文明疾病。 目的：综述质谱在代谢性疾病脂质分析中的应用。 方法：在广泛查阅同类文献的基础上，对脂质的质谱分析进行了综述。 结果：脂质组约含有170万种，在脂肪链长度、环数、附加功能组等方面完全不同。其中一些是如此复杂，以至于他们的复杂分析对分析师来说是一个挑战。它们的定性和定量分析主要基于质谱法。 结论：质谱技术是复杂生物样品中脂质谱分析的良好工具，结合多元统计分析可以识别潜在的诊断生物标志物。

关键词: 综合技术，脂肪酸，气相色谱，液相色谱，代谢疾病，质谱成像，磷脂，鸟枪脂质。

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