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Current Cancer Drug Targets


ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

Review Article

Autophagy as a Potential Therapeutic Target in Breast Cancer Treatment

Author(s): Natalia Lisiak*, Ewa Toton and Maria Rybczynska

Volume 18, Issue 7, 2018

Page: [629 - 639] Pages: 11

DOI: 10.2174/1568009617666171114143330

Price: $65


One of the crucial reasons of breast cancer therapy failure is an impairment of mechanisms responsible for metabolism and cellular homeostasis, which makes it difficult to foresee the response to the treatment. Targeted therapy in breast cancer is dictated by the expression of specific molecules such as growth factor or hormone receptors. Many types of breast cancer exhibit different abnormalities in the apoptotic pathway, which confer the resistance to many forms of chemotherapy. Because of the fundamental importance of autophagy in the development and progression of cancer and its ability to affect treatment response, there has been an immense research on molecular regulation and signal transduction mechanisms that control this process. Here, we summarize the present knowledge concerning different breast cancer treatment strategies using drugs approved for the treatment of different breast cancer molecular subtypes with targeting pathways and factors associated with autophagy modulation/ regulation.

Keywords: Autophagy, breast cancer, targeted therapy, receptors, HDAC, lysosomes, microtubules.

Graphical Abstract

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