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Anti-Cancer Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

General Research Article

Design, Synthesis and Anti-breast Cancer Activity of Some Novel Substituted Isoxazoles as Anti-breast Cancer Agent

Author(s): Santosh N. Mokale*, Nikhil S. Sakle, Swati A. Bhavale, Deepak K. Lokwani and Vishakha R. Shelke

Volume 18, Issue 7, 2018

Page: [1009 - 1015] Pages: 7

DOI: 10.2174/1871520618666171129153655

Price: $65

Abstract

Methods: A novel series of isoxazole (S21-S30) derivatives were designed, synthesized and screened for their anticancer activity against estrogen receptor-positive MCF-7 and negative MDA-MB-435 breast cancer cell lines. The synthesized derivative has the ability to inhibit the growth of the human breast cancer cell line at low concentrations. In vivo anticancer activity was performed on virgin female sprague dawley rats.

Results: The result shows that compound S23 has more selectivity and marked estrogen modulator activity than the standard tamoxifen.

Keywords: Chalcone, isoxazole, breast cancer, estrogen receptor, S21-S30, tamoxifen.

Graphical Abstract

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