Abstract
Background: Stereotactic body radiotherapy (SBRT) or radiosurgery has emerged as a viable highly precise technique that delivers a hypofractionated radiotherapy regimen with a high biologic effective dose. In addition to patient convenience, this dose is thought to provide acceptable local control while keeping toxicity to a minimum due to the typical small target size. The aims of this paper are to review recent outcomes with the application of SBRT in the management of head and neck cancer.
Methods: Research and online content related to head and neck cancer SBRT were reviewed focusing on dose fractionation schedules, incorporation of systemic therapy and long term toxicity.
Results: SBRT technique provided convenient precise approach in the management of primary as well as recurrent head and neck cancer with adequate local control rates and tolerable long term toxicity profile.
Conclusion: The use of stereotactic body radiotherapy is still evolving and multiple studies are needed to optimize the dose fractionation of SBRT and its integration with systemic therapy.
Keywords: Streotactic Body Radiotherapy (SBRT), Head and Neck Cancer (HNC), toxicity, hypofractionation, Squamous Cell Carcinoma (SCC), carcinoma.
Current Cancer Therapy Reviews
Title:Stereotactic Body Radiation Therapy in Head and Neck Squamous Cell Carcinoma: Science or Art?
Volume: 14 Issue: 1
Author(s): Rashi Garg and Omar Mahmoud*
Affiliation:
- Department of Radiation Oncology, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ,United States
Keywords: Streotactic Body Radiotherapy (SBRT), Head and Neck Cancer (HNC), toxicity, hypofractionation, Squamous Cell Carcinoma (SCC), carcinoma.
Abstract: Background: Stereotactic body radiotherapy (SBRT) or radiosurgery has emerged as a viable highly precise technique that delivers a hypofractionated radiotherapy regimen with a high biologic effective dose. In addition to patient convenience, this dose is thought to provide acceptable local control while keeping toxicity to a minimum due to the typical small target size. The aims of this paper are to review recent outcomes with the application of SBRT in the management of head and neck cancer.
Methods: Research and online content related to head and neck cancer SBRT were reviewed focusing on dose fractionation schedules, incorporation of systemic therapy and long term toxicity.
Results: SBRT technique provided convenient precise approach in the management of primary as well as recurrent head and neck cancer with adequate local control rates and tolerable long term toxicity profile.
Conclusion: The use of stereotactic body radiotherapy is still evolving and multiple studies are needed to optimize the dose fractionation of SBRT and its integration with systemic therapy.
Export Options
About this article
Cite this article as:
Garg Rashi and Mahmoud Omar *, Stereotactic Body Radiation Therapy in Head and Neck Squamous Cell Carcinoma: Science or Art?, Current Cancer Therapy Reviews 2018; 14 (1) . https://dx.doi.org/10.2174/1573394714666180122143310
DOI https://dx.doi.org/10.2174/1573394714666180122143310 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
Call for Papers in Thematic Issues
Current progress in Protein Degradation and Cancer Therapy
argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Regulation of Tumor Immune Microenvironment by Sphingolipids and
Lysophosphatidic Acid
Current Drug Targets Saccharomyces Cerevisiae as a Genetic Model in Anticancer Therapy
Current Pharmacogenomics Development of Lymphatic Vessels: Tumour Lymphangiogenesis and Lymphatic Invasion
Current Medicinal Chemistry Liposomal-All-trans-Retinoic Acid in the Treatment of Acute Promyelocytic Leukemia
Current Cancer Therapy Reviews Ginkgolic Acids Confer Potential Anticancer Effects by Targeting Pro- Inflammatory and Oncogenic Signaling Molecules
Current Molecular Pharmacology Molecular Dynamics Simulations of Proteins and Peptides: From Folding to Drug Design
Current Protein & Peptide Science Anti-cancer Drug Delivery Using Metal Organic Frameworks (MOFs)
Current Medicinal Chemistry Abscopal Effect of Radiation Therapy and Signal Transduction
Current Signal Transduction Therapy Injectable Thermosensitive Chitosan/Glycerophosphate-Based Hydrogels for Tissue Engineering and Drug Delivery Applications: A Review
Recent Patents on Drug Delivery & Formulation Emerging Family of Protein-protein Interaction Inhibitors Targeting PD-1 Checkpoint Pathway
Current Cancer Therapy Reviews Therapeutic Potential, Synthesis, Patent Evaluation and SAR Studies of Thieno[3,2-d]pyrimidine Derivatives: Recent Updates
Current Drug Targets Role of Protein Tyrosine Phosphatase in Regulation of Cell Signaling Cascades Affecting Tumor Cell Growth: A Future Perspective as Anti-Cancer Drug Target
Current Pharmaceutical Biotechnology Targeting Microtubules to Inhibit Angiogenesis and Disrupt Tumour Vasculature:Implications for Cancer Treatment
Current Cancer Drug Targets Vascular Endothelial Growth Factor (VEGF) as a Target of Bevacizumab in Cancer: From the Biology to the Clinic
Current Medicinal Chemistry Diagnostic Accuracy of Ultrasound for the Evaluation of Lateral Compartment Lymph Nodes in Papillary Thyroid Carcinoma
Current Medical Imaging New Developments in Antimicrobial Use in Sepsis
Current Pharmaceutical Design Tyrosine Kinases as Molecular Targets to Inhibit Cancer Progression and Metastasis
Current Pharmaceutical Design Synthesis and Anti-tumor Activities of Novel Phenyl Substituted Suberoylanilide Hydroxamic Acid Derivatives Against Human Cancer Cells
Medicinal Chemistry Targeting RhoA/Rho Kinase and p21-Activated Kinase Signaling to Prevent Cancer Development and Progression
Recent Patents on Anti-Cancer Drug Discovery Olfactory Dysfunction and Cognitive Impairment in Age-Related Neurodegeneration: Prevalence Related to Patient Selection, Diagnostic Criteria and Therapeutic Treatment of Aged Clients Receiving Clinical Neurology and Community-Based Care
Current Clinical Pharmacology