摘要
背景:阿尔茨海默病(AD)诊断的最新研究主要集中在神经影像学模式上,但这些方法昂贵、侵入性强,并非所有患者都能使用。b型眼显像边缘视网膜的多标记物,如DRUSEN,可为AD的诊断提供一种新的方法。 目的:比较对照组和AD组的黄斑和外周膜疣负荷。 方法:取供者经病理诊断为AD的死后眼组织。正常供体的视网膜被处理并分类为较年轻(<55岁)和年龄(>55岁)。RS)组。固定和解剖后,在黄斑部和周边(颞、上、下)视网膜区域中取3-6mm的RPE /脉络膜穿孔。油红O阳性玻璃疣计数分为两大类:小(<63μm)和中间(63-125μm)。 结果:老年组黄斑部和周围硬膜部的总数目明显高于正常组(P<0.05)。中间硬鼓风较常见。AD眼颞区ND与老年性正常眼相比,即使控制年龄,也有显着性差异(P<0.05)。在AD供者的大脑和眼睛组织中,两者之间存在着显著的相关性。n脑淀粉样血管病变(CAA)的严重程度和颞中硬组织的数目(r=0.78,p<0.05)。结论:眼内颞叶DRUSEN显像对诊断和诊断有一定的价值。AD环进展我们对AD眼CAA严重程度和颞中位DRUSEN的研究结果是新的。为了进一步了解CAA和drusen形式之间的相互作用,还需要进一步的研究。增强辐射,文明阶段.
关键词: 阿尔茨海默病,周围性痴呆,生物标志物,颞叶视网膜,眼睛,大脑。
Current Alzheimer Research
Title:Drusen in the Peripheral Retina of the Alzheimer’s Eye
Volume: 15 Issue: 8
关键词: 阿尔茨海默病,周围性痴呆,生物标志物,颞叶视网膜,眼睛,大脑。
摘要: Background: Recent work on Alzheimer's disease (AD) diagnosis focuses on neuroimaging modalities; however, these methods are expensive, invasive, and not available to all patients. Ocular imaging of biomarkers, such as drusen in the peripheral retina, could provide an alternative method to diagnose AD.
Objective: This study compares macular and peripheral drusen load in control and AD eyes.
Methods: Postmortem eye tissues were obtained from donors with a neuropathological diagnosis of AD. Retina from normal donors were processed and categorized into younger (<55 years) and older (>55 years) groups. After fixation and dissection, 3-6 mm punches of RPE/choroid were taken in macular and peripheral (temporal, superior, and inferior) retinal regions. Oil red O positive drusen were counted and grouped into two size categories: small (<63 μm) and intermediate (63-125 μm).
Results: There was a significant increase in the total number of macular and peripheral hard drusen in older, compared to younger, normal eyes (p<0.05). Intermediate hard drusen were more commonly found in the temporal region of AD eyes compared to older normal eyes, even after controlling for age (p<0.05). Among the brain and eye tissues from AD donors, there was a significant relationship between cerebral amyloid angiopathy (CAA) severity and number of temporal intermediate hard drusen (r=0.78, p<0.05).
Conclusion: Imaging temporal drusen in the eye may have benefit for diagnosing and monitoring progression of AD. Our results on CAA severity and temporal intermediate drusen in the AD eye are novel. Future studies are needed to further understand the interactions among CAA and drusen formation.
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Cite this article as:
Drusen in the Peripheral Retina of the Alzheimer’s Eye, Current Alzheimer Research 2018; 15 (8) . https://dx.doi.org/10.2174/1567205015666180123122637
DOI https://dx.doi.org/10.2174/1567205015666180123122637 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
Call for Papers in Thematic Issues
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Aims and Scope: Introduction: Alzheimer's disease (AD) poses a significant global health challenge, with an increasing prevalence that demands concerted efforts to advance our understanding and strategies for prevention, diagnosis, treatment, and rehabilitation. This thematic issue aims to bring together cutting-edge research and innovative approaches from multidisciplinary perspectives to address ...read more
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Current updates on the Role of Neuroinflammation in Neurodegenerative Disorders
Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
Deep Learning for Advancing Alzheimer's Disease Research
Alzheimer's disease (AD) poses a significant global health challenge, with an increasing number of individuals affected yearly. Deep learning, a subfield of artificial intelligence, has shown immense potential in various domains, including healthcare. This thematic issue of Current Alzheimer Research explores the application of deep learning techniques in advancing our ...read more
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