Abstract
Biginelli compounds are one of the most important heterocyclic systems that play an important role in medicinal chemistry. It has been proved that the biological activities of these compounds are dependent on the absolute configuration of the C4 atom of the heterocyclic ring, and thus the oxidative dehydrogenation reaction can affect their biological and pharmaceutical activities. In this review, the oxidation methods of various Biginelli compounds have been summarized with a focus on the conditions of the reactions, the proposed mechanisms, and the effect of the substituents on the reaction.
Keywords: Biginelli reaction, oxidation, dehydrogenation, 2-oxo-1, 2, 3, 4-tetrahydropyrimidine, 2-thioxo-1, 2, 3, 4-tetrahydropyrimidine, dihydropyrimidinone, pyrimidinone, pyrimidine.
Current Organic Chemistry
Title:Advances in the Oxidation of Biginelli Compounds
Volume: 22 Issue: 9
Author(s): Mousa Soleymani*
Affiliation:
- Department of Chemistry, Faculty of Science, University of Ayatollah Alozma Borujerdi, Borujerd,Iran
Keywords: Biginelli reaction, oxidation, dehydrogenation, 2-oxo-1, 2, 3, 4-tetrahydropyrimidine, 2-thioxo-1, 2, 3, 4-tetrahydropyrimidine, dihydropyrimidinone, pyrimidinone, pyrimidine.
Abstract: Biginelli compounds are one of the most important heterocyclic systems that play an important role in medicinal chemistry. It has been proved that the biological activities of these compounds are dependent on the absolute configuration of the C4 atom of the heterocyclic ring, and thus the oxidative dehydrogenation reaction can affect their biological and pharmaceutical activities. In this review, the oxidation methods of various Biginelli compounds have been summarized with a focus on the conditions of the reactions, the proposed mechanisms, and the effect of the substituents on the reaction.
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Cite this article as:
Soleymani Mousa *, Advances in the Oxidation of Biginelli Compounds, Current Organic Chemistry 2018; 22 (9) . https://dx.doi.org/10.2174/1385272822666180129144507
DOI https://dx.doi.org/10.2174/1385272822666180129144507 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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