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Current Drug Targets


ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Antioxidants in Peripheral Arterial Disease

Author(s): F. Violi, L. Loffredo, A. Mancini and A. Marcoccia

Volume 4, Issue 8, 2003

Page: [651 - 655] Pages: 5

DOI: 10.2174/1389450033490786

Price: $65


Peripheral arterial disease (PAD) is an important manifestation of systemic atherosclerosis that is characterized by obstruction of the arteries in the lower limbs. Experimental and epidemiological studies suggested a key role for oxidative stress in initiation and progression of the atherosclerotic process. The results of these studies provided a good basis for interventional trials with antioxidants, particularly with vitamin E, but the findings were conflicting. In this paper we review the observational and interventional studies with antioxidants, and ask whether vitamins supplementation should or should be not be recommended for PAD patients.

Keywords: peripheral arterial disease, oxidative stress, antioxidants, atherosclerosis

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