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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

Ryanodine Receptors for Drugs and Insecticides: An Overview

Author(s): Zhiqiang Sun and Hui Xu*

Volume 19, Issue 1, 2019

Page: [22 - 33] Pages: 12

DOI: 10.2174/1389557518666180330112908

Price: $65


Ryanodine receptors (RyRs) are calcium channels located on the endo(sarco)plasmic reticulum of muscle cells and neurons. They regulate the release of stored intracellular calcium and play a critical role in muscle contraction. The N-terminal part of these receptors accounts for roughly 80% and contains the binding sites for diverse RyRs modulators. The C-terminal domain contains the transmembrane region. This review summarizes the current knowledge about the molecular biology of insect RyRs, chemicals targeting mammal or insect RyRs, and the reasons for mammal RyR-related diseases and diamides resistances. It may lay the foundation for effective management of mammal RyR-related diseases and diamides resistances.

Keywords: Ryanodine, ryanodine receptors, mammal RyR-related diseases, diamides insecticides, insecticide resistant, MicroRNA.

Graphical Abstract
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