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Current Pharmaceutical Biotechnology


ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

Review Article

The Critical Role of Abnormal Trophoblast Development in the Etiology of Preeclampsia

Author(s): Berthold Huppertz*

Volume 19, Issue 10, 2018

Page: [771 - 780] Pages: 10

DOI: 10.2174/1389201019666180427110547

open access plus


Background: The pregnancy pathology preeclampsia is still among the leading causes of maternal and perinatal morbidity and mortality. At the same time, its etiology is far from being identified and remains obscure in a number of facets.

A number of hypotheses have been developed to explain the altered interplay between placenta and mother leading to the clinical symptoms of preeclampsia. However, none of them offers the opportunity to explain the variability of cases with late-onset versus early-onset, mild versus severe and with or without additional fetal growth restriction.

Conclusion: This paper identifies the weaknesses of the most important current hypothesis and at the same time offers a set of new elucidations including maternal susceptibility, and villous/extravillous trophoblast differentiation to explain the development of preeclampsia. Such elucidations allow following new scientific routes and pathways to untangle the etiology of preeclampsia.

Keywords: Aponecrosis, extravillous trophoblast, fetal growth restriction, trophoblast invasion, placental oxygenation, preeclampsia, syncytiotrophoblast, villous trophoblast.

Graphical Abstract

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