Abstract
In the post-genomic era, microarray technology will have a major impact on our understanding of complex gene expression patterns and circuit function in the brain. Due to the phenotypic and transcript complexity of the brain, transcriptome profiling data is multifaceted, and is best interpreted in the context of the cellular diversity of the studied brain region. In the near future, massive microarray datasets will be placed into a biological context. To separate biologically significant transcriptome differences from experimental noise, verification of microarray data and anatomical localization of expression changes to neuronal subpopulations will continue to be an integral part of microarray experiments.
Keywords: Microarrays
Current Genomics
Title: Microarrays in Brain Research: Data Quality and Limitations
Volume: 3 Issue: 1
Author(s): Karoly Mirnics
Affiliation:
Keywords: Microarrays
Abstract: In the post-genomic era, microarray technology will have a major impact on our understanding of complex gene expression patterns and circuit function in the brain. Due to the phenotypic and transcript complexity of the brain, transcriptome profiling data is multifaceted, and is best interpreted in the context of the cellular diversity of the studied brain region. In the near future, massive microarray datasets will be placed into a biological context. To separate biologically significant transcriptome differences from experimental noise, verification of microarray data and anatomical localization of expression changes to neuronal subpopulations will continue to be an integral part of microarray experiments.
Export Options
About this article
Cite this article as:
Mirnics Karoly, Microarrays in Brain Research: Data Quality and Limitations, Current Genomics 2002; 3(1) . https://dx.doi.org/10.2174/1389202023350598
DOI https://dx.doi.org/10.2174/1389202023350598 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |

- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
- Forthcoming Thematic Issues
Related Articles
-
Dysregulation of SIRT-1 Signaling in Multiple Sclerosis and Neuroimmune Disorders: A Systematic Review of SIRTUIN Activators as Potential Immunomodulators and their Influences on other Dysfunctions
Endocrine, Metabolic & Immune Disorders - Drug Targets Update on Alzheimer’s Disease Therapeutics
Reviews on Recent Clinical Trials Proton Magnetic Resonance Spectroscopy as a Monitoring Tool for Electroconvulsive Therapy Effects on the Brain
Current Psychiatry Reviews Development of Anti-Viral Agents Using Molecular Modeling and Virtual Screening Techniques
Infectious Disorders - Drug Targets Bruton's Tyrosine Kinase Inhibition in the Treatment of Preclinical Models and Multiple Sclerosis
Current Pharmaceutical Design The Role of 18 kDa Mitochondrial Translocator Protein (TSPO) in Programmed Cell Death, and Effects of Steroids on TSPO Expression
Current Molecular Medicine Oiling the Pipeline: The Path from Genomics to Drug Discovery for Brain Disease
Current Drug Targets - CNS & Neurological Disorders Prevalence of Drug Resistance Associated Mutations Among the Anti Retroviral Therapy Exposed HIV-1 Infected Individuals in Manipur, Northeast India
Current HIV Research Vitamin, Mineral, and Drug Absorption Following Bariatric Surgery
Current Drug Metabolism Nutritional Assessment in the Critically Ill Child
Current Pediatric Reviews Oral Inflammation and Bacteremia: Implications for Chronic and Acute Systemic Diseases Involving Major Organs
Cardiovascular & Hematological Disorders-Drug Targets High-Throughput Proteomics: A New Tool for Quality and Safety in Fishery Products
Current Protein & Peptide Science Nucleoprotein-Derived and Unbound Ribonucleosides: Bioactivity and Potential Applications
Current Pharmaceutical Design Nanotechnology Applications for Diffuse Intrinsic Pontine Glioma
Current Neuropharmacology Antiapoptotic Drugs: A Therapautic Strategy for the Prevention of Neurodegenerative Diseases
Current Pharmaceutical Design The Role and Impact of SNPs in Pharmacogenomics and Personalized Medicine
Current Drug Metabolism Recent Advances in the Use of Cyclodextrins in Antifungal Formulations
Current Topics in Medicinal Chemistry The Endocrine Regulation of Stem Cells: Physiological Importance and Pharmacological Potentials for Cell-Based Therapy
Current Stem Cell Research & Therapy Relevance of Breast Cancer Resistance Protein to Brain Distribution and Central Acting Drugs: A Pharmacokinetic Perspective
Current Drug Metabolism On the Future Development of Optimally-Sized Lipid-Insoluble Systemic Therapies for CNS Solid Tumors and Other Neuropathologies
Recent Patents on CNS Drug Discovery (Discontinued)