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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Development of IL-5 Receptor Antagonists

Author(s): Iain Uings and Murray McKinnon

Volume 8, Issue 20, 2002

Page: [1837 - 1844] Pages: 8

DOI: 10.2174/1381612023393800

Price: $65


A wealth of both clinical and pre-clinical data has strongly implicated the eosinophil in the pathogenesis of asthma, highlighting this cell type as a potential target for novel anti-inflammatory approaches to asthma therapy. The Th2 lymphocyte derived cytokine Interleukin-5 (IL-5) has emerged as the key regulator of eosinophil production, thus identifying IL-5 as the principal molecular target for therapeutic intervention. This review highlights both the pharmaceutical approaches, and the major challenges, to the identification of small molecule and protein antagonists of the IL-5 receptor. Using examples of known inhibitors we discuss their current status and highlight the major development hurdles in progressing these molecules into the market place.

Keywords: receptor antagonists, granulocyte-macrophage, bronchial hyperreactivity, constrained peptides

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