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Current Diabetes Reviews


ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

Systematic Review Article

Studying the Gut Microbiome of Latin America and Hispanic/Latino Populations. Insight into Obesity and Diabetes: Systematic Review

Author(s): Romero-Ibarguengoitia Maria Elena*, Garcia-Dolagaray Gabriela, Gonzalez-Cantu Arnulfo and Caballero Augusto Enrique

Volume 15, Issue 4, 2019

Page: [294 - 301] Pages: 8

DOI: 10.2174/1573399814666180730124817

Price: $65


Background: People from Latin America (LA) and the Hispanic/Latino community living in the United States (LUS) exhibit a high prevalence of diabetes (DM) and obesity (OB). The Gut Microbiome (GM) is capable of altering energy regulation and glucose metabolism, but for the expression of these diseases a combination of multiple factors such as ethnicity, genetic and nutritional factors are required. A systematic research was conducted to understand if the prevalence of OB and/or DM has an interaction with the GM in LA and LUS.

Methods: Research was conducted in PubMed, Web of Science, Scielo, Embase and Google Scholar for articles between 1990 and 2017. It was restricted to human studies published in English, Spanish, or Portuguese that applied genetic techniques to study the GM in LA or LUS and discussed the association with OB and/or DM.

Results: Different gut Firmicutes/Bacteroidetes relationships in several populations from LA influenced by geography, diet and lifestyles interacted with OB. Healthy people from the Mexico and US border had the same imbalance between Firmicutes and Bacteroidetes found in OB or Type 2 DM. High levels of Bacteroides and a reduced proportion of Prevotella, Megamonas, and Acidaminococcus were found in newly diagnosed type 1 DM. Once the patient was treated with insulin, an increase of Prevotella levels was seen. Inverse Firmicutes/Bacteroidetes relationship was reported before the development of Type 1 DM.

Conclusion: An important relation between GM and OB and/or DM exists in LA and LUS. Further elucidation of pathophysiologic mechanisms is required.

Keywords: Gut microbiome, diabetes, obesity, latinos, latin america, systematic review.

Caballero AE. Understanding the hispanic/latino patient. Am J Med 2011; 124(10): S10-5.
Heiss G, Snyder ML, Teng Y, et al. Prevalence of metabolic syndrome among hispanics/latinos of diverse background: the hispanic community health study/study of latinos. Diabetes Care 2014; 37(8): 2391-9.
Márquez-Sandoval F, Macedo-Ojeda G, Viramontes-Hörner D, Fernández Ballart J, Salas Salvadó J, Vizmanos B. The prevalence of metabolic syndrome in Latin America: a systematic review. Public Health Nutr 2011; 14(10): 1702-13.
Federation ID. IDF Diabetes Atlas 6th 2015.
Daviglus ML, Pirzada A, Talavera GA. Cardiovascular disease risk factors in the hispanic/latino population: lessons from the hispanic community health study/study of latinos (HCHS/SOL). Prog Cardiovasc Dis 2014; 57(3): 230-6.
Rodriguez CJ, Daviglus ML, Swett K, et al. Dyslipidemia patterns among hispanics/latinos of diverse background in the United States. Am J Med 2014; 127(12): 1186-1194.e1.
Spanakis EK, Golden SH. Race/ethnic difference in diabetes and diabetic complications. Curr Diab Rep 2013; 13(6): 814-23.
Turnbaugh PJ, Hamady M, Yatsunenko T, et al. A core gut microbiome in obese and lean twins. Nature 2009; 457(7228): 480-4.
Ursell LK, Metcalf JL, Parfrey LW, Knight R. Defining the human microbiome. Nutr Rev 2012; 70: S38-44.
Arumugam M, Raes J, Pelletier E, et al. Enterotypes of the human gut microbiome. Nature 2011; 473(7346): 174-80.
Peterson DA, Frank DN, Pace NR, Gordon JI. Metagenomic approaches for defining the pathogenesis of inflammatory bowel diseases. Cell Host Microbe 2008; 3(6): 417-27.
Qin J, Li R, Raes J, Arumugam M, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 2010; 464(7285): 59-65.
Morgan XC, Huttenhower C. . Chapter 12: Human Microbiome Analysis. Lewitter F, Kann M, Eds. PLoS Comput Biol 2012. Dec 27; 8(12): e1002808
Caballero AE. Type 2 diabetes in the Hispanic or Latino population: challenges and opportunities. Curr Opin Endocrinol Diabetes Obes 2007; 14(2): 151-7.
Moher D, Liberati A, Tetzlaff J, Altman DG. The PRISMA Group.Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Med 2009; 6(7): e1000097.
Backhed F, Ding H, Wang T, et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci 2004; 101(44): 15718-23.
Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006; 444(7122): 1027-131.
Armougom F, Henry M, Vialettes B, Raccah D, Raoult D. Monitoring bacterial community of human gut microbiota reveals an increase in lactobacillus in obese patients and methanogens in anorexic patients. Ratner AJ, Ed. PLoS One. 2009; 4(9): e7125..
Schwiertz A, Taras D, Schäfer K, et al. Microbiota and SCFA in lean and overweight healthy subjects. Obesity 2010; 18(1): 190-5.
Tims S, Derom C, Jonkers DM, et al. Microbiota conservation and BMI signatures in adult monozygotic twins. ISME J 2013; 7(4): 707-17.
Murugesan S, Ulloa-Martínez M, Martínez-Rojano H, et al. Study of the diversity and short-chain fatty acids production by the bacterial community in overweight and obese Mexican children. Eur J Clin Microbiol Infect Dis 2015; 34(7): 1337-46.
Estrada-Velasco BI, Cruz M, García-Mena J, et al. La obesidad infantil como consecuencia de la interacción entre firmicutes y el consumo de alimentos con alto contenido energético. Nutr Hosp 2015; 31(3)
Radilla-Vázquez RB, Parra-Rojas I, Martínez-Hernández NE, Márquez-Sandoval YF, Illades-Aguiar B, Castro-Alarcón N. Gut microbiota and metabolic endotoxemia in young obese mexican subjects. Obes Facts 2016; 9(1): 1-11.
Mayorga RL, González VR, Cruz ASM, et al. Correlation between diet and gut bacteria in a population of young adults. Int J Food Sci Nutr 2016; 67(4): 470-8.
Escobar JS, Klotz B, Valdes BE, Agudelo GM. The gut microbiota of Colombians differs from that of Americans, Europeans and Asians. BMC Microbiol [Internet]. 2014 Dec [Cited on 2017 Dec 7]; 14(1). Available from: http://bmcmicrobiol.biomedcentral. com/articles/10.1186/s12866-014-0311-6
Teixeira TFS, Grześkowiak LM, Salminen S, Laitinen K, Bressan J. Peluzio M do CG. Faecal levels of Bifidobacterium and Clostridium coccoides but not plasma lipopolysaccharide are inversely related to insulin and HOMA index in women. Clin Nutr 2013; 32(6): 1017-22.
Karlsson FH, Tremaroli V, Nookaew I, et al. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature 2013; 498(7452): 99-103.
Qin J, Li Y, Cai Z, et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 2012; 490(7418): 55-60.
Le Chatelier E, Nielsen T, Qin J, et al. Richness of human gut microbiome correlates with metabolic markers. Nature 2013; 500(7464): 541-6.
Remely M, Aumueller E, Jahn D, Hippe B, Brath H, Haslberger AG. Microbiota and epigenetic regulation of inflammatory mediators in type 2 diabetes and obesity. Benef Microbes 2014; 5(1): 33-43.
Larsen N, Vogensen FK, van den Berg FWJ, et al. gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. Bereswill S, Ed. PLoS One 2010; 5(2): e9085..
Ross MC, Muzny DM, McCormick JB, Gibbs RA, Fisher-Hoch SP, Petrosino JF. 16S gut community of the Cameron County Hispanic Cohort. Microbiome 2015; 3(1): 7.
Mejía-León ME, Petrosino JF, Ajami NJ, Domínguez-Bello MG, de la Barca AMC. Fecal microbiota imbalance in Mexican children with type 1 diabetes Sci Rep [Internet]. 2015 May [Cited on: 2017 Dec 7]; 4(1). Available from: .
Mejía-León ME, Calderón de la Barca AM. Perinatal factors and type 1 diabetes-associated dysbiosis in Mexican infants. Bol Méd Hosp Infant México 2015; 72(5): 333-8.
Mejía-León ME, Petrosino JF, Ajami NJ, Domínguez-Bello MG, de La Barca AMC. Fecal microbiota imbalance in Mexican children with type 1 diabetes. Sci Rep 2014; 4: 3814.
van Dijk EL, Auger H, Jaszczyszyn Y, Thermes C. Ten years of next-generation sequencing technology. Trends Genet 2014; 30(9): 418-26.
Taddei CR, Oliveira FF, Duarte RTD, et al. High Abundance of Escherichia During the Establishment of Fecal Microbiota in Brazilian Children. Microb Ecol 2014; 67(3): 624-34.
Paul B, Barnes S, Demark-Wahnefried W, et al. Influences of diet and the gut microbiome on epigenetic modulation in cancer and other diseases Clin Epigenetics [Internet]. 2015 Dec [Cited on: 2018 Jul 15]; 7(1). Available from: .
Potaczek DP, Harb H, Michel S, Alhamwe BA, Renz H, Tost J. Epigenetics and allergy: From basic mechanisms to clinical applications. Epigenomics 2017; 9(4): 539-71.

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