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Current Stem Cell Research & Therapy


ISSN (Print): 1574-888X
ISSN (Online): 2212-3946

Review Article

Recent Advances of Useful Cell Sources in the Periodontal Regeneration

Author(s): Young-Dan Cho, Kyoung-Hwa Kim, Hyun-Mo Ryoo, Yong-Moo Lee, Young Ku and Yang-Jo Seol*

Volume 14, Issue 1, 2019

Page: [3 - 8] Pages: 6

DOI: 10.2174/1574888X13666180816113456

Price: $65


Background: Periodontitis is an inflammatory disease that can result in destruction of the tooth attachment apparatus. Therefore, periodontal tissue regeneration is currently an important focus of research in the field. Approaches using stem cells and reprogrammed cells, such as induced pluripotent stem cells (iPSCs) or trans-differentiated cells, represent the cutting edge in periodontal regeneration, and have led to many trials for their clinical application.

Objectives and Results: In this review, we consider all available stem cell sources, methods to obtain the cells, their capability to differentiate into the desired cells, and the extent of their utilization in periodontal regeneration. In addition, we introduce the new concepts of using iPSCs and transdifferentiated cells for periodontal regeneration. Finally, we discuss the promise of tissue engineering for improving cell therapy outcomes for periodontal regeneration.

Conclusions: Despite their limitations, iPSCs and trans-differentiated cells may be promising cell sources for periodontal tissue regeneration. Further collaborative investigation is required for the effective and safe application of these cells in combination with tissue engineering elements, like scaffolds and biosignals.

Keywords: Stem cells, cell reprogramming, induced pluripotent stem cells, trans-differentiation, periodontal tissue regeneration, tissue engineering.

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