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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Translation of Basic Research into Clinics: Killer Immunoglobulin-like Receptors Genes in Autoimmune and Infectious Diseases

Author(s): Anna Aiello*, Giuseppina Candore*, Giulia Accardi, Calogero Caruso, Claudia Colomba, Giovanni Duro, Caterina Maria Gambino, Mattia Emanuela Ligotti and Danilo Di Bona

Volume 24, Issue 26, 2018

Page: [3113 - 3122] Pages: 10

DOI: 10.2174/1381612824666180911123249

Price: $65


Killer immunoglobulin-like receptors (KIRs) regulate the activation of natural killer cells through their interaction with human leucocyte antigens (HLA). KIRs and HLA loci are highly polymorphic, and some of their combinations have been found to protect against viral infections or to predispose to autoimmune disorders. In particular, some activating KIRs profiles may be detrimental in autoimmune pathogenesis, and specific KIRs may be particularly aggressive in the clearance of different microorganisms, protecting individuals in the control of a given pathogen. So, considering that in the pathogenesis of many autoimmune disorders and infections innate immunity plays a key role, the recent development for KIRs characterization, diseases monitoring, and treatment becomes obvious. Here, we reviewed a growing body of evidence supporting the influence of KIRs variants and their interaction with ligands in the development of the main human autoimmune and viral diseases, highlighting the main applications in clinical practice.

Keywords: Autoimmune diseases, HLA ligands, immunogenetics, KIRs, translational medicine, viral infections.

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