Abstract
The recent progress in synthetic and SAR studies of the specific protein phosphatase inhibitors tautomycin and tautomycetin is reviewed. This article covers the total synthesis of tautomycin and synthetic studies of the spiroketal and the anhydride segments and tautomycetin, and SAR studies on PP inhibition and apoptosis-inducing activity of tautomycin.
Keywords: Protein, Phosphatase Inhibitors, Tautomycin, Tautomycetin, apoptosis
Current Medicinal Chemistry
Title: Synthesis of Specific Protein Phosphatase Inhibitors, Tautomycin and Tautomycetin toward Structure-Activity Relationship Study
Volume: 9 Issue: 22
Author(s): H. Oikawa
Affiliation:
Keywords: Protein, Phosphatase Inhibitors, Tautomycin, Tautomycetin, apoptosis
Abstract: The recent progress in synthetic and SAR studies of the specific protein phosphatase inhibitors tautomycin and tautomycetin is reviewed. This article covers the total synthesis of tautomycin and synthetic studies of the spiroketal and the anhydride segments and tautomycetin, and SAR studies on PP inhibition and apoptosis-inducing activity of tautomycin.
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Cite this article as:
Oikawa H., Synthesis of Specific Protein Phosphatase Inhibitors, Tautomycin and Tautomycetin toward Structure-Activity Relationship Study, Current Medicinal Chemistry 2002; 9 (22) . https://dx.doi.org/10.2174/0929867023368818
DOI https://dx.doi.org/10.2174/0929867023368818 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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