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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Review Article

Stealth Peptides Target Cellular Powerhouses to Fight Rare and Common Age-Related Diseases

Author(s): Hazel H. Szeto*

Volume 25, Issue 12, 2018

Page: [1108 - 1123] Pages: 16

DOI: 10.2174/0929866525666181101105209

Price: $65

Abstract

Background: Mitochondria are the primary source of energy in most tissues. Mitochondrial dysfunction results in cellular energy deficiency, triggers the production of reactive oxygen species, and initiates various cell death and inflammatory pathways. Several cell-permeable peptides (SS peptides) have been described that selectively target cardiolipin on the inner mitochondrial membrane and promote efficiency of the electron transport chain to produce more ATP.

Conclusion: In preclinical disease models, these peptides have been shown to repair damaged mitochondria and promote cellular repair and restore function. By mitigating cell injury, these peptides prevent inflammatory responses that can result in chronic inflammation and tissue remodeling. This peptide technology platform represents a paradigm shift in targeting the fundamental cause of cellular energy failure for age-related degenerative diseases.

Keywords: Aromatic-cationic peptides, mitochondria, cardiolipin, SS-31, elamipretide, reactive oxygen species, apoptosis, autophagy, inflammasome.

Graphical Abstract

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