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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Cancer-Homing Toxins

Author(s): H. C. Ng and H. E. Khoo

Volume 8, Issue 22, 2002

Page: [1973 - 1985] Pages: 13

DOI: 10.2174/1381612023393477

Price: $65

Abstract

Cancer-homing toxins are a group of man-made cytotoxic molecules targeting cancer cells. In the past decade they have demonstrated potential as cancer therapeutics. These molecules contain a toxin, natural or usually derivatized, connected to a cancerhoming module, such as a monoclonal antibody or growth factor or their derivatives. Various cancer-homing toxins have been designed and tested in cell-lines, animalmodels and clinical trials. We review some of these data and discuss ways to better design cancer-homing toxins in the light of advances in cancer genomics, antibodyengineering techniques and computational algorithms.

Keywords: Downregulation, Toxins, Targeted-therapy, Cancer, Vascular-leak syndrome, Drug- design, Super-antigen, Clinicaltrials


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