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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Diagnoses of Pathological States Based on Acetylcholinesterase and Butyrylcholinesterase

Author(s): Miroslav Pohanka*

Volume 27, Issue 18, 2020

Page: [2994 - 3011] Pages: 18

DOI: 10.2174/0929867326666190130161202

Price: $65


Two cholinesterases exist: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). While AChE plays a crucial role in neurotransmissions, BChE has no specific function apart from the detoxification of some drugs and secondary metabolites from plants. Thus, both AChE and BChE can serve as biochemical markers of various pathologies. Poisoning by nerve agents like sarin, soman, tabun, VX, novichok and overdosing by drugs used in some neurodegenerative disorders like Alzheimer´s disease and myasthenia gravis, as well as poisoning by organophosphorus pesticides are relevant to this issue. But it appears that changes in these enzymes take place in other processes including oxidative stress, inflammation, some types of cancer and genetically conditioned diseases. In this review, the cholinesterases are introduced, the mechanism of inhibitors action is explained and the relations between the cholinesterases and pathologies are explained.

Keywords: Acetylcholinesterase, anesthesia, butyrylcholinesterase, diagnosis, liver function test, myorelaxant, nerve agent, neurotransmission, pesticide, poisoning.

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