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Combinatorial Chemistry & High Throughput Screening


ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Mimotopes of Viral Antigens and Biologically Important Molecules as Candidate Vaccines and Potential Immunotherapeutics

Author(s): C. D. Partidos and M. W. Steward

Volume 5, Issue 1, 2002

Page: [15 - 27] Pages: 13

DOI: 10.2174/1386207023330589

Price: $65


Antigen recognition by antibodies or ligand-receptor interactions involve small areas of the molecule named epitopes that are normally conformational in nature. The availability of combinatorial peptide libraries has provided a powerful tool for selecting novel sequences which mimic conformational epitopes (mimotopes) either structurally and / or immunologically. These mimotopes can be particularly useful in a number of situations, including: the development of vaccines against tumors, infectious diseases or allergic conditions the design of molecules which can act as agonists or antagonists of various biologically-important molecules and for the development of diagnostic assays. This article reviews the authors work on the application of combinatorial peptide libraries to identify mimotopes of protective B-cell epitopes from various pathogens, and the search for molecules able to block the biological activities of TNF-α, a cytokine which plays a key role in inflammation.

Keywords: Mimotopes, Viral Antigens, epitopes, measles virus mv, respiratory syncytial virus rsv, schistosoma mansoni, mouth disease virus fmdv

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