Abstract
Current theories of dopaminergic and noradrenergic mechanisms, which are thought to be of importance in the regulation of attention are reviewed. A biphasic model of dopaminergic function is described, in which tonic dopamine exerts a suppressive influence on subcortical dopamine systems by altering tonic/phasic dopaminergic relationships. Noradrenergic mechanisms are of importance in modulating sensory processing at the prefrontal cortical level. The work of Silberstein and colleagues utilizing Steady-State Visually Evoked Potential, during the course of an A-X Continuous Performance Task enables examination of the spatial distribution and dynamics of electrical brain activity during the task. The maintenance of activation in the interval between A and X provides a measure of working memory, thought to be related to prefrontal-parietal activation, which is facilitated by administration of methylphenidate to children with ADHD, suggesting that working memory may be a core deficiency in children with ADHD. While tonic dopamine activity in vental striatum/accumbens gates inhibitory activity, dorsolateral prefrontal-parietal connections allow maintenance of working memory required for goal completion.
Current Drug Targets
Title: Working Memory in ADHD: Prefrontal/Parietal Connections
Volume: 2 Issue: 4
Author(s): F Levy and M Farrow
Affiliation:
Abstract: Current theories of dopaminergic and noradrenergic mechanisms, which are thought to be of importance in the regulation of attention are reviewed. A biphasic model of dopaminergic function is described, in which tonic dopamine exerts a suppressive influence on subcortical dopamine systems by altering tonic/phasic dopaminergic relationships. Noradrenergic mechanisms are of importance in modulating sensory processing at the prefrontal cortical level. The work of Silberstein and colleagues utilizing Steady-State Visually Evoked Potential, during the course of an A-X Continuous Performance Task enables examination of the spatial distribution and dynamics of electrical brain activity during the task. The maintenance of activation in the interval between A and X provides a measure of working memory, thought to be related to prefrontal-parietal activation, which is facilitated by administration of methylphenidate to children with ADHD, suggesting that working memory may be a core deficiency in children with ADHD. While tonic dopamine activity in vental striatum/accumbens gates inhibitory activity, dorsolateral prefrontal-parietal connections allow maintenance of working memory required for goal completion.
Export Options
About this article
Cite this article as:
Levy F and Farrow M, Working Memory in ADHD: Prefrontal/Parietal Connections, Current Drug Targets 2001; 2 (4) . https://dx.doi.org/10.2174/1389450013348155
DOI https://dx.doi.org/10.2174/1389450013348155 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Brain Connectivity Studies in Schizophrenia: Unravelling the Effects of Antipsychotics
Current Neuropharmacology MicroRNA-Targeted Signaling Pathways in the Autism Spectrum Disorder: Implications for Early Detection and Targeted Therapy
CNS & Neurological Disorders - Drug Targets Selectivity and Affinity Determinants for Ligand Binding to the Aromatic Amino Acid Hydroxylases
Current Medicinal Chemistry Neuropsychological Findings in Obsessive-Compulsive Disorder and its Potential Implications for Treatment
Current Psychiatry Reviews Mechanisms of Immune Responsiveness Against Influenza Virus in Lungs and Modulation with Dietary Products
Clinical Immunology, Endocrine & Metabolic Drugs (Discontinued) Meet Our Editorial Board Member
CNS & Neurological Disorders - Drug Targets Advanced Tools of Regenerative Medicine for Neurodegenerative Diseases
Recent Patents on Regenerative Medicine Pharmacotherapy and the Psychobiological Model of Personality: Implications for DSM-5
Current Psychopharmacology A Review of the Hypoglycemic Effects of Five Commonly Used Herbal Food Supplements
Recent Patents on Food, Nutrition & Agriculture Pharmacokinetic and Pharmacodynamic Aspects of Peyote and Mescaline: Clinical and Forensic Repercussions
Current Molecular Pharmacology Prediction of Human Drug Metabolizing Enzyme Induction
Current Drug Metabolism Recent Development in [1,4]Benzodiazepines as Potent Anticancer Agents: A Review
Mini-Reviews in Medicinal Chemistry Evidence Based Psychosocial Practices and Recovery from Schizophrenia
Current Psychiatry Reviews Pharmacological Perspectives of Ayurvedic Herbs <i>viz. Alstonia scholaris</i> L., <i>Picrorhiza kurroa, Swertia chirata</i> and <i>Caesalpinia crista</i> Against COVID- 19: A Mini-Review
Mini-Reviews in Organic Chemistry A Novel Approach to Refractory Epilepsy by Targeting Pgp Peripherally and Centrally: Therapeutic Targets and Future Perspectives
CNS & Neurological Disorders - Drug Targets Mouse Models of Familial Hemiplegic Migraine for Studying Migraine Pathophysiology
Current Neuropharmacology Editorial [Hot Topic: Calcium Regulatory Proteins as Therapeutic Targets (Guest Editor: Livia C. Hool)]
Current Drug Targets Conformational Analysis of Opioid Peptides in the Solid States and the Membrane Environments by NMR Spectroscopy
Current Topics in Medicinal Chemistry Diffusion Tensor Imaging in Alzheimers Disease
Current Medical Imaging The Effect of Sodium Metabisulphite on Apoptosis in the Experimental Model of Parkinson’s Disease
Current Nutrition & Food Science