Abstract
It was demonstrated that a gene or genes responsible for a whole spectrum of cardiovascular risk factors map to a limited segment of the centromeric region of rat chromosome 4. Recently, a spontaneous deletion in the gene for Cd36 that encodes a fatty acid transporter and is located directly at the peak of QTL linkages on chromosome 4 has been indirectly linked to the transmission of insulin resistance, defective fatty acid metabolism, and increased blood pressure. To directly test whether mutant Cd36 is a QTL that promotes clustering of multiple cardiovascular risk factors in the Spontaneously Hypertensive Rat (SHR), transgenic lines were derived that carry a wild type Cd36 transgene on the genetic background of the SHR strain harboring a deletion variant of Cd36. It was found that in SHR harboring the deletion variant of Cd36, transgenic expression of wild type Cd36 in modest amounts ameliorated defects in fatty acid metabolism, glucose tolerance, and insulin stimulated glucose uptake in muscle and fat tissue, however, exerted little or no effect on blood pressure. In conclusion, the current studies provided definitive evidence that mutant Cd36 is a QTL with major effects on fatty acid metabolism, insulin action, and glucose tolerance but have no effects on spontaneous hypertension in the SHR/NIH strains.
Keywords: CD36, Cardiovascular Risk Factor, Hypertensive Rat, INSULIN RESISTANCE, DYSLIPIDEMIA, HYPERTENSION, TRANSGENIC SHR
Current Genomics
Title: Identification of Defective CD36 as a Quantitative Trait Locus for Cardiovascular Risk Factor Clustering in the Spontaneously Hypertensive Rat
Volume: 2 Issue: 2
Author(s): M. Pravenec, V. Landa, V. Zidek and V. Kren
Affiliation:
Keywords: CD36, Cardiovascular Risk Factor, Hypertensive Rat, INSULIN RESISTANCE, DYSLIPIDEMIA, HYPERTENSION, TRANSGENIC SHR
Abstract: It was demonstrated that a gene or genes responsible for a whole spectrum of cardiovascular risk factors map to a limited segment of the centromeric region of rat chromosome 4. Recently, a spontaneous deletion in the gene for Cd36 that encodes a fatty acid transporter and is located directly at the peak of QTL linkages on chromosome 4 has been indirectly linked to the transmission of insulin resistance, defective fatty acid metabolism, and increased blood pressure. To directly test whether mutant Cd36 is a QTL that promotes clustering of multiple cardiovascular risk factors in the Spontaneously Hypertensive Rat (SHR), transgenic lines were derived that carry a wild type Cd36 transgene on the genetic background of the SHR strain harboring a deletion variant of Cd36. It was found that in SHR harboring the deletion variant of Cd36, transgenic expression of wild type Cd36 in modest amounts ameliorated defects in fatty acid metabolism, glucose tolerance, and insulin stimulated glucose uptake in muscle and fat tissue, however, exerted little or no effect on blood pressure. In conclusion, the current studies provided definitive evidence that mutant Cd36 is a QTL with major effects on fatty acid metabolism, insulin action, and glucose tolerance but have no effects on spontaneous hypertension in the SHR/NIH strains.
Export Options
About this article
Cite this article as:
Pravenec M., Landa V., Zidek V. and Kren V., Identification of Defective CD36 as a Quantitative Trait Locus for Cardiovascular Risk Factor Clustering in the Spontaneously Hypertensive Rat, Current Genomics 2001; 2 (2) . https://dx.doi.org/10.2174/1389202013350995
DOI https://dx.doi.org/10.2174/1389202013350995 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Advanced AI Techniques in Big Genomic Data Analysis
The thematic issue on "Advanced AI Techniques in Big Genomic Data Analysis" aims to explore the cutting-edge methodologies and applications of artificial intelligence (AI) in the realm of genomic research, where vast amounts of data pose both challenges and opportunities. This issue will cover a broad spectrum of AI-driven strategies, ...read more
Advanced Computational Algorithms and Artificial Intelligence in Clinical Pharmacogenomics
In the era of personalized medicine, understanding the relationship between genetics and drug response is crucial. This issue delves into innovative methodologies, leveraging deep computational analysis and artificial intelligence, to enhance the field of Clinical Pharmacogenomics. The interdisciplinary approach harnesses the power of advanced high-throughput genotyping technologies, sophisticated computational analysis, ...read more
Applications of Single-cell Sequencing Technology in Reproductive Medicine
Single cell sequencing (SCS) technology utilizes individual cells' genetic material to sequence their genome, transcriptome, and epigenetics at the molecular level. It offers insights into cell heterogeneity and enables the study of limited biological materials. Since its recognition as a valuable technique in 2011, single cell sequencing has yielded numerous ...read more
Big Data in Cancer Research
Cancer is a significant threat to human life and health, remaining a highly aggressive killer. It is a leading cause of death worldwide and represents a crucial medical issue for humanity. However, in the past decade, the effectiveness of new synthetic anticancer agents has not matched the current clinical speculation. ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Vitamins in Heart Failure: Friend or Enemy?
Current Pharmaceutical Design Editorial [Hot topic: Targets of Research in the Metabolic Syndrome (Guest Editor: Lindsay Brown)]
Endocrine, Metabolic & Immune Disorders - Drug Targets Development and Optimization of Controlled Release Bioerodable Anti Infective Ophthalmic Insert
Current Drug Delivery Is There any Correlation Between Diabetic Retinopathy and Risk of Cardiovascular Disease?
Current Diabetes Reviews Oral Factor Xa (FXa) Inhibitors for Treatment of Heparin-induced Thrombocytopenia (HIT)
Current Drug Therapy The Endothelium and Platelets in Cardiovascular Disease: Potential Targets for Therapeutic Intervention
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Effects of Maternal Obesity on Maternal and Fetal Health
Current Women`s Health Reviews Oxidative Stress and Lipid Peroxidation in Prolonged Users of Methamphetamine
Drug Metabolism Letters An Apple Plus a Brazil Nut a Day Keeps the Doctors Away: Antioxidant Capacity of Foods and their Health Benefits
Current Pharmaceutical Design Design and Synthesis of Thiazolidinedione Derivates as Selective PPARγ Modulators
Letters in Drug Design & Discovery Markers of Arrhythmogenic Risk in Hypertensive Subjects
Current Pharmaceutical Design Complex Obesity
Current Pediatric Reviews Vacuolar H+-ATPase Signaling Pathway in Cancer
Current Protein & Peptide Science Demonstration of the Efficacy of Statins in Resolution of Plaque Inflammation by Serial FDG Imaging
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Antidiabetic Drugs as Antihypertensives: New Data on the Horizon
Current Vascular Pharmacology Novel Neuroendocrine and Metabolic Mechanism Provides the Patented Platform for Important Rejuvenation Therapies: Targeted Therapy of Telomere Attrition and Lifestyle Changes of Telomerase Activity with the Timing of Neuron-Specific Imidazole-Containing Dipeptide-Dominant Pharmaconutrition Provision
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery On the Structural Basis of the Hypertensive Properties of Angiotensin II: A Solved Mystery or a Controversial Issue?
Current Topics in Medicinal Chemistry Myocardial Infarction after Rituximab Treatment for Rheumatoid Arthritis: Is there a Link?
Current Pharmaceutical Design Micronized Purified Flavonoid Fraction (MPFF)*: A Review of its Pharmacological Effects, Therapeutic Efficacy and Benefits in the Management of Chronic Venous Insufficiency
Current Vascular Pharmacology Is Type D Personality Here to Stay? Emerging Evidence Across Cardiovascular Disease Patient Groups
Current Cardiology Reviews