Frontiers in Biomaterials

Volume: 5

Stem Cells and Scaffolds: Strategies for Musculoskeletal System Tissue Engineering

Author(s): Mahboubeh Nabavinia, Ding Weng, Yi-Nan Zhang and Wanting Niu

Pp: 131-169 (39)

DOI: 10.2174/9781681085784117050009

* (Excluding Mailing and Handling)


Musculoskeletal system mainly includes bone, cartilage, tendon, ligament, and skeletal muscle, which supports the body and connects tissues and organs together. Musculoskeletal disorders, including degenerative diseases and trauma injuries lead to the loss of part tissue, and always accompanied with pain. With the development of biomaterials, developmental biology, nanomedicine and orthopedic therapy strategies, tissue engineering of musculoskeletal system has been well investigated in the past two decades. Many musculoskeletal tissue repair strategies have achieved success in animal models, with part of them entered clinical trials which will benefit patients in the future.

Keywords: Bone, Cartilage, Decellularized scaffolds, Hybrid materials, Ligament, Natural polymers, Skeletal muscle, Stem cells, Synthetic polymers, Tendon, Tissue engineering.

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