Bone Marrow Aspirate Concentrate and Expanded Stem Cell Applications in Orthopaedics

Role of BMAC in Avascular Necrosis

Author(s): Tomek Kowalski, Mohamed A. Imam, Kuen Chin and Martyn Snow

Pp: 75-79 (5)

DOI: 10.2174/9781681086491118010013

* (Excluding Mailing and Handling)


Avascular necrosis (AVN) is characterized by cell death of trabecular bone leading to bone collapse and subsequent joint destruction. Recently, application of bone marrow derived MSCs has been proposed as adjunctive treatment to core decompression for osteonecrosis of femoral head. There have been several studies, which report that BMAC application results in the improvement of outcomes; nevertheless, it is dependent on the stage of osteonecrosis. Superior outcomes are reported, similar to bone preserving procedures in the pre collapse stages. Additionally, the technique has not been associated with any significant complications. The current results are encouraging, however, more studies are required.

Keywords: Avascular necrosis, Bone Marrow, Bone Marrow Aspirate Concentrate (BMAC), Osteonecrosis, Stem Cells.

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