Today, there are major environmental challenges associated with hazardous waste management in India. In this regard, hazardous production is increasing rapidly and it's required proper management to be improving the future of India. In this context, the Indian government's policy and legislation are not working properly on Hazardous Waste Management (HWM), thereby triggering enormous public health issues. The effective Hazardous waste (HW) treatment practices are of paramount importance to protect human health, and in addition, this is a social responsibility for the safety of the future generation. This chapter reviews the current situation on the rules and regulations of HWM and policy to adopt new successful approaches and techniques that are used worldwide to address this issue in India. Current systems in India cannot cope with the volumes of waste generated by an increasing urban population because of the lack of adequate infrastructure but these challenges will allow to transforming barriers in good opportunities for sustainable growth.