In this chapter, we briefly discussed the bottlenecks commonly present for
using the surface enhanced Raman spectroscopy (SERS) in research. The barriers in the
successful commercialization of this technique are also highlighted in this chapter. This
chapter is also dedicated to the account of possible key strategies for improvement of
SERS. Among these strategies, we discussed one of the promising strategies based on
improved nanofabrication at length. Furthermore, few recent important developments
in SERS instrumentation and handheld portable devices are also highlighted in this
chapter for providing broader information to the readers.