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The Evolution of Radionanotargeting towards Clinical Precision Oncology: A Festschrift in Honor of Kalevi Kairemo

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Theragnostics in Austria

Author(s): Irene Virgolini * .

Pp: 232-245 (14)

DOI: 10.2174/9781681088655122010021

* (Excluding Mailing and Handling)

Abstract

Over the past decades, Professor Kalevi Kairemo has been a well-known and
dear colleague with whom we have excellently cooperated, especially via the
international organisations IAEA (International Atomic Energy Agency) and The
WARMTH (World Association of Radiopharmaceutical and Molecular Therapy). The
work resulted in the construction of radiotracers using different modal systems,
including a variety of radiolabelled peptide analogues such as somatostatin,
cholecystokinin (CCK-2/gastrin), or prostate-specific membrane antigen (PSMA)
ligand for specific tumour targeting. Radiopharmaceuticals are produced at clinical
grade in dedicated laboratories for use in SPECT/CT or PET/CT studies. Patients
evaluated by SPECT/CT dosimetry studies are treated with high dose thera(g)nostics.
Radioiodine ablation therapy of thyroid cancer remnants, peptide receptor radionuclide
therapy (PRRT) of NET patients, and peptide ligand radionuclide therapy (PLRT) of
PC patients are today the most important therapeutic tools.

Keywords: Peptide Receptor Radionuclide Therapy, Peptide ligand Radionuclide Therapy, Radioiodine Refractory Thyroid Cancer, Hormone Refractory Prostate Cancer, Neuroendocrine Tumours, Thera(g)nostics.

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