“Fit for Purpose” 64Cu Labeled Liposome Formulations Specialized for Enriched Targeting to 1) Bone Marrow Spleen; 2) lymph Nodes; or 3) Tumor

Pp: 272-276 (5)

* (Excluding Mailing and Handling)

Upon intravenous injection, liposomal particles are rapidly cleared from the

blood by fixed macrophages in the liver, spleen, bone marrow and lymph nodes i.e.

specialized cells of the innate immune system. By reducing the affinity for these fixed

macrophages, therapeutic liposomes containing drugs have been used to target tumor

by the Enhanced Permeability and Retention (EPR) effect. In this communication, we

report minor modifications of lipid compositions that result in the production of 3

classes of liposomes, each suitable for enhanced selectivity of uptake in 1) Bone

Marrow/Spleen (SBMT Lipo); 2) Lymph Nodes (LNT Lipo); and 3) Tumor (TT Lipo).

Keywords: Bone Marrow Imaging, Copper-64, Endothelial Macrophages, Lymph Node Imaging, Nanoparticles, PET, Reticuloendothelial System, Tumor Imaging.

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