Bone Targeted Radionuclide Therapy in Russia From Beta- to Alpha- Emitters

Pp: 368-383 (16)

* (Excluding Mailing and Handling)

Treatment of patients with painful multiple bone metastases is a complicated

clinical task. Radionuclide therapy is one of the solutions, which is used to achieve the

long reduction of pain syndrome and to significantly improve the quality of life.

However, the mechanism of action of bone-seeking radiopharmaceuticals suggests not

only pain control but the antitumor effect as well. In early clinical studies of safety and

efficacy, single administrations of the most common bone-seeking

radiopharmaceuticals did not demonstrate any benefit in overall survival, but individual

extraordinary tumor regressions were reported. Repeated administrations and

combination with other treatment modalities can help to gain a statistically significant

increase in overall survival. In this chapter, the history of bone-targeted radionuclide

therapy in Russia is reviewed.

Keywords: 89Sr-chloride, 153Sm-EDTMP, 153Sm-Oxabifor, 188Re-HEDP, 188Rezoledronic acid, 223Rа-chloride, Bone Metastases, Bone Pain Palliation, Bone- Targeted Radionuclide Therapy.

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