Molecular Radiobiology and Radionuclides Therapy Concepts

Radionuclides therapy (RNT) development is a multidisciplinary endeavor.

It requires expertise in radiochemistry, radiobiology, oncology, pharmacology, medical

physics, and nuclear medicine. Many pharmaceutical companies are not familiar with

the aspects of radiation and radionuclide therapy, and the deployment of RNT agents

for cancer therapy is also unfamiliar to the oncology community. When compared with

almost all other systemic cancer treatment options, RNT has shown efficacy with

minimal toxicity. Moreover, molecular radiobiology needs to be further explored to

gain knowledge of the bystander's radiation effect. It can lead to updating for systemic

radionuclide therapy concept. This paper aims to review radiation biology and

radionuclides concepts to better understand the importance of basic concepts of

ionizing radiation, particularly for a systemic cancer treatment option.

Keywords: Alpha particle, Auger electrons, Beta particle, Radionuclide induced bystander effects, Radionuclide targeted therapy, The abscopal effect.

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