Frontiers in Clinical Drug Research - CNS and Neurological Disorders

Volume: 10

A Review of the Impact of Testosterone on Brain and Aging-related Decline in Brain Behavioural Function

Author(s): Adejoke Y Onaolapo* and Olakunle J Onaolapo

Pp: 314-335 (22)

DOI: 10.2174/9789815040678122100009

* (Excluding Mailing and Handling)


The hormone testosterone is known to affect a variety of functions in the
body, a number of which are related to behaviour, and preservation of brain neuronal
integrity. Along this line, certain experimental evidences suggest that testosterone
supplementation may be beneficial in the preservation of cognitive functions and
neuronal integrity in aging and may be a valuable addition to a growing arsenal of
medications that can be used to combat aging-related cognitive decline. However, some
other studies have suggested instances where testosterone supplementation may be
deleterious for the brain neurons, while under certain conditions, the likely effects of
testosterone supplement may not be clear. Some studies had even suggested that race
may be a major determinant of testosterone’s effects on the brain. In this review, salient
aspects of testosterone’s effects on the brain are discussed with emphasis on its
behavioural and morphological effects. The impacts of aging on the behavioural and
brain morphological effects of testosterone are also discussed, with emphasis on its
nootropic effects. The limitations to the clinical application of testosterone in
mitigating aging related cognitive decline are also considered.

Keywords: Aging, Androgen, Cognition, Hypothalamopituitary Axis, Neurobehaviour, Neuroprotection.

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