Molecular Targets and Cancer Therapeutics (Part 1)

Cell Signaling Pathways in Cancer

Author(s): Hajir A. Al-Saihati*, Mashael Al-Toub, Hanaa I. Sharaf, Manjari Singh, Mohd. Nazam Ansari and Abdulaziz Bin Saeedan

Pp: 242-272 (31)

DOI: 10.2174/9789815080384123010009

* (Excluding Mailing and Handling)


Cancer is characterized by atypical cell proliferation that has the possibility of dissemination to different body parts. Tumor formation is influenced by genetic mutations and environmental pollutants. The formation and progression of malignancies have been linked to a diversity of molecular paths. The JAK/STAT, NOTCH, PI3K/AKT pathway, mitogen-activated protein kinase (MAPK), transforming growth factor-beta (TGF-beta) (TGF-), NF-B, and Wnt signaling pathways will be highlighted in this chapter. Cancer development has been linked to various changes to the signaling pathways' components. As a result, various initiatives to target signaling pathways in order to build distinct treatment lines have been approved. In this chapter, we discuss the role of signal transduction in cancer-associated processes and how their targets influence the behavior of the tumor cells.

Keywords: Cancer, JAK/STAT, Map Kinase/Erk, NFκB, Notch, PI3K/AKT/mTOR, TGF-β, Wnt/β catenin.

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