Cancer Genes

Chromosome 1

Author(s): Ravi Gor, Saurav Panicker and Satish Ramalingam * .

Pp: 1-27 (27)

DOI: 10.2174/9789815080292123010004

* (Excluding Mailing and Handling)


Chromosome 1 is the largest human chromosome, constituting approximately 249 million base pairs. Chromosome 1 is the largest metacentric chromosome, with “p” and “q” arms of the chromosome almost similar in length. Chromosome 1 abnormalities or inclusion of any mutations leads to developmental defects, mental, psychological, cancer, etc., among the most common diseases. 1/10th of the genes in chromosome 1 have been reported its involvement in cancer growth and development. These cancer genes result from chromosomal rearrangement, fusion genes, somatic mutations, point mutation, gene insertion, gene deletion, and many more. Some of these cancer-causing genes appear to be involved in cancer more often, and other novel genes are also enlisted in this chapter.

Keywords: Cancer, Developmental defects, Fusion gene, Gene, Gene insertion, Gene deletion, Metacentric, Mutation, p-arm, Point mutation, Psychological, qarm, Somatic mutation.

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