Cancer Genes

Chromosome 7

Author(s): Muthu Vijai Bharath Vairamani, Harini Hariharan and Satish Ramalingam * .

Pp: 223-242 (20)

DOI: 10.2174/9789815080292123010010

* (Excluding Mailing and Handling)


Chromosome 7 consists of 159 million base pairs, and around 950 genes, representing at least 5 percent of the entire DNA in a cell. Various genes that regulate cell division and cellular growth are present in Chromosome 7. Aberrations in these genes can therefore lead to tumorigenesis. Lymphomas and Leukemia have been frequently correlated with abnormalities on chromosome 7. Aberrations in chromosome 7, such as aneusomy in prostate cancer, gene amplifications in gastric cancer, and chromosomal gain in glioblastoma, are some of the starkly real ramifications of genetic abnormalities on chromosome 7. Numerous essential genes from Chromosome 7, including ABCB5, BRAF, CDK6, EGFR, ETV1, EZH2, IL6, and TWIST1, involved in cancer have been explained in this chapter.

Keywords: Liver cancer, Breast cancer, Colorectal cancer, Esophageal cancer, Gastric cancer, Leukemia, Lymphoma, Melanoma, Ovarian cancer, Pancreatic cancer, Prostate cancer, Renal cancer.

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