Cancer Genes

Chromosome 9

Author(s): Thilaga Thirugnanam, Yamini Chandrapraksh, Sivasankari Ramadurai, Abhishek Mitra, Ravi Gor, Saurav Panicker and Satish Ramalingam * .

Pp: 287-306 (20)

DOI: 10.2174/9789815080292123010012

* (Excluding Mailing and Handling)


Chromosome 9 represents approximately 4.5 percent of the total DNA in cells, and it’s a submetacentric type of chromosome. Chromosomal abnormalities in chromosome 9 have been reported in different kinds of cancer, for example, deletion of the long-q arm, a fusion of ABL1 with BCR results in the ABL1-BCR fusion gene, etc. Bladder cancer, chronic myeloid leukemia, etc., are several cancer types resulting from genetic changes in the genes present in chromosome 9. Dysregulation of the tumor suppressor genes or activation of the oncogene from chromosome 9 has supported the normal cell’s transformation. Here, we have listed a few top genes reappearing themselves as causative agent for cancer development in cancer and types of cancer.

Keywords: ABL1-BCR, Bladder Cancer, Chromosomal Abnormalities, Chronic Myeloid Leukemia, Fusion Gene, Genetic Change, Oncogene, q-arm, Submetacentric, Tumor Suppressor.

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