Cancer Genes

Chromosome 10

Author(s): Saurav Panicker and Satish Ramalingam * .

Pp: 307-343 (37)

DOI: 10.2174/9789815080292123010013

* (Excluding Mailing and Handling)


Chromosome 10 contains various genes that are significantly involved in tumorigenesis. These genes described herein that play roles in cancer comprise receptor tyrosine kinases (FGFR2), proto-oncogenes (FRAT1, RET), tumor suppressor genes (PTEN, KLF6), and also genes involved in signal transduction (MAPK8), gene fusions (CCDC6, KIF5B, VTI1A), developmental processes (GATA3, NODAL), Epithelial- Mesenchymal transition (ZEB1, VIM) and epigenetic regulation (MLLT10). This chapter provides a compilation of many such genes from Chromosome 10 that are associated with cancer, with vivid delineations of the underlying molecular mechanisms of each gene in its contribution to cancer initiation, progression and metastasis. Genes that are insufficiently investigated but implicated in tumorigenesis have also been described in this chapter.

Keywords: Apoptosis, Cell Cycle, Cytogenetic Location, Deletion, Downregulation, Gene, Gene Amplification, Invasion, Malignant, Migration, Mutation, Signal Transduction, Translocation, Tumor Progression, Upregulation.

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