The Role of Chromenes in Drug Discovery and Development

The Implication of Chromene Derivatives in Bioactive Admixtures

Author(s): Dheeraj Bisht*, Deepak Sati, Rajeshwar Kamal Kant Arya, Amit Kumar Nigam, Monu Kumar Shukla and Deepak Kumar

Pp: 225-234 (10)

DOI: 10.2174/9789815124330123010013

* (Excluding Mailing and Handling)


Chromene is a heterocyclic scaffold and can be obtained from the natural origin (from different fractions of the plant extracts), synthetic origin as well as mineral origin. The nucleus of the scaffold possesses the ability to interact with different biological targets and thus is medicinally active. Chromene derivatives obtained from different origins are reported to possess pharmacological activities such as antitumor, antibacterial, anti-inflammatory, antithrombotic, and antipsychotic activities. Many chromene-based admixtures are reported to possess different bioactivities. Many derivatives of chromene, such as isomiroestrol, deoxymiroestrol, and miroestrol have been investigated as phytoestrogens. Along with therapeutic potencies, chromene glycosides have safety, efficacy, and stability in the form of herbal drugs and cosmetics. So, the chapter focuses on chromene derivatives, their biological sources, respective bioactivities, and recent advancements. 

Keywords: Admixtures, Chromenes, Extracts, Heterocyclic scaffold, Phytoestrogens, Staphylococcus aureus.

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