Cancer Genes

Chromosome X

Author(s): Anusha Mandem, Saurav Panicker, Abhishek Mitra and Satish Ramalingam * .

Pp: 334-365 (32)

DOI: 10.2174/9789815136500123020013

* (Excluding Mailing and Handling)


X Chromosome is the sex chromosome that is found in many organisms. Both males and females, including mammalians, have X Chromosomes. Females have XX sets of chromosomes, and males have XY sets of chromosomes. X Chromosome aids in identifying the sex of the organism. The Human X chromosome contains approximately 1500 genes. These genes may undergo some genetic alterations and eventually lead to complex diseases. Genetic mutations in some of the genes of the X chromosome are associated with cancer. Some specific mutations are observed in human cancer cells. This chapter specifically relayed on X chromosomal genes that are associated with different types of cancer and gave information on the location of the gene in the X chromosome. Moreover, the function of the specific gene and information regarding how many types of cancers were associated with a particular gene, has also been provided.

Keywords: Ceruloplasmin, Chromosome Condensation, Chromosome Fragmentation, Cowchock Syndrome, Hepatocellular Carcinoma, Leiomyomatosis, Malignant, Microtubule, Ovarian Cancers, Recessive, Simpson Dysmorphia, X-linked.

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