Cancer Genes

Chromosome Y

Author(s): Sowmiya Sattanathan, Saurav Panicker and Satish Ramalingam * .

Pp: 366-382 (17)

DOI: 10.2174/9789815136500123020014

* (Excluding Mailing and Handling)

Abstract

Sex chromosome constitution vary genetically in both genders, such as XY in male and XX in female. Even though the chromosomes X and Y advanced from the autosomal pair of the same ancestor, male-specific genes were harbored by the Y chromosome. This Y chromosome plays a crucial role in germ cell differentiation, sex determination in males, and numerous tissue masculinization. Translocations or deletions of SRY, the sex-determining gene of the Y chromosome, enable sex development disorders with dysgenic gonads. Gonadal improvement failure outturns not only in infertility but also in the highest possibilities of GCT (Germ Cell Tumour), like various kinds of testicular GCT and gonad blastoma. Studies have shown that selected somatic cancers are closely related to both losses of Y chromosome genes, ectopic expression, or Y chromosome. These observations remark that genes of the Y chromosome are associated with male diseases and health more than attic turns out not only in infertility but also in the highest possibilities of GCT (Germ Cell Tumour) like various kindspated. Even though only a compact amount of protein-coding genes are seen in Y chromosomes male-specific region, the effects of those Y chromosomal genes on human disease are still predominantly unknown. In this part, we can find the participation of selected genes of the Y chromosome in cancer growth in men.


Keywords: Chromosome Y, Gonads, Male fertility, Melatonin, Prostate cancer, Sex chromosome, SRY, Tumor, Ubiquitin.

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