Natural Products for Treatment of Skin and Soft Tissue Disorders

Superficial Mycoses as a Challenging Skin Disorder

Author(s): Wiwit Suttithumsatid and Pharkphoom Panichayupakaranant * .

Pp: 50-79 (30)

DOI: 10.2174/9789815124361123010006

* (Excluding Mailing and Handling)

Abstract

Superficial mycoses of the skin, nails and hair caused by dermatophytes, non-dermatophyte molds, yeasts and yeast-like fungi are among the most common morbidity of the skin, especially in tropical regions of the world. Various antifungal agents, including polyenes, fluoropyrimidines, echinocandins, and azoles, have been commonly used, topically and/or orally, for the treatment of superficial mycoses. Nevertheless, the conventional treatment guideline is not always successful due to drug resistance as well as the possibility of drug interactions and side effects. Recently, the search for new antifungal compounds, such as naphthoquinones, anthraquinones, terpenoids, saponins and flavonoids from medicinal plants toward novel drug development, has attracted a lot of attention. This chapter describes the common superficial mycoses as well as their pathophysiology, epidemiology and current treatment options. Promising herbal extracts or phytochemicals and their products used as therapeutic alternatives for combating superficial mycosis are also highlighted.


Keywords: Antifungal, Candidiasis, Dermatophytes, Phytochemicals, Superficial mycoses, Tinea versicolor.

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