Frontiers In Medicinal Chemistry

Carcinogenicity of Hexavalent Chromium and Its Effects

Author(s): Sachin Verma, Pallavi Kumari, Shailesh Kumar and Ashok Kumar Jha * .

Pp: 205-213 (9)

DOI: 10.2174/9789815165043123100009

* (Excluding Mailing and Handling)

Abstract

Hexavalent chromium has been a potential threat to human beings due to its toxicity and carcinogenesis. The pathway of entry of hexavalent chromium in an aqueous medium is both anthropogenic and natural through ores of chromium. Prolonged exposure to hexavalent chromium may cause DNA mismatch and gene mutation, resulting in cancer. Cr(VI)- induced malignant cell and its study has become very important towards the possible mechanism of Cr(VI) binding. When a cell of the human lungs adsorbs hexavalent chromium due to prolonged ingestion of Cr(VI) contaminated water or inhalation, oxidative DNA damage is caused in the specific gene. This causes mutations in adenine and guanine bases of DNA in cases of lung cancer.


Keywords: Cr(VI), Carcinogenicity, DNA, Mutation.

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