Treatment of cancer does not depend on a single drug and the existing strategies are challenged by the the frequent development of drug resistance properties of cancer cells. Although chemotherapy drugs are still used as the first line of treatment modalities for cancer, immunotherapyis also used as a targeted treatment modality nowadays. However, major challenge with the treatment is that, patient recovery is very low. Therefore, combination therapies are being investigated and some of them are at the clinical stage with FDA approval. In this chapter, we will discuss currently available immunotherapy drugs and their synergistic effects in combination with chemotherapy drugs or two different immunotherapy drugs.