Fetal Alcohol Spectrum Disorders (FASD) constitutes a serious worldwide health problem that persists, despite prevention efforts. This chapter examines preclinical research on methods to reduce the severity of FASD, either during the period of prenatal alcohol exposure or during postnatal development. Some prenatal treatments focus on directly blocking or minimizing alcohol's mechanisms of teratogenic action. The possibility that nutritional supplements during prenatal alcohol exposure may reduce the severity of FASD is also explored. Finally, treatments that may be effective even after the alcohol insult, during postnatal development are examined, including nutritional, pharmacological, and environmental/behavioral interventions. Many exciting and effective treatments for FASD have been identified and the challenge is now to translate these findings to clinical populations.