Abstract
Polycyclic aromatic hydrocarbons (PAHs) are a class of ubiquitous contaminants produced by natural or anthropogenic processes and found in various environment and food samples. A number of PAHs are carcinogenic and listed as priority pollutants in a variety of regulations. For a long time, much public attention has been drawn on PAHs due to the sensitive issue of environmental risks and food safety. In recent years, immunoassay methods have been applied in environmental and food analysis of PAHs and employed as highly sensitive, selective and cost-effective alternative to complement traditional chromatographic analysis. In this article, the rapid progress in the immunoassays for analysis of PAHs in food and environmental samples, such as selecting haptens, producing antibodies and developing immunoanalytical methods, has been reviewed. Since there was a comprehensive review published in 2002, this article is mainly focusing on the achievements since 2002 in this field. Some significant works before 2002 are also included. Although there have been quite a few antibodies and immunoassays for PAHs available, more novel antibodies and immunoanalytical methods are still welcome. Moreover, class-selective determinations and quantitative structure-activity relationship (QSAR) techniques are likely to play an important role in PAHs immunoassays in the future.
Keywords: Immunoassay, ELISA, PAHs, benzo[a]pyrene, hapten, antibody.
Current Organic Chemistry
Title:Antibody Development and Immunoassays for Polycyclic Aromatic Hydrocarbons (PAHs)
Volume: 21 Issue: 26
Author(s): Yan-Feng Zhang*Zhi-Xian Gao
Affiliation:
- Tianjin Key Laboratory of Environmental Remediation and Pollution Control, MOE Key Laboratory of Pollution Processes and Environmental Criteria, College of Environmental Science and Engineering, Nankai University, Tianjin 300350,China
Keywords: Immunoassay, ELISA, PAHs, benzo[a]pyrene, hapten, antibody.
Abstract: Polycyclic aromatic hydrocarbons (PAHs) are a class of ubiquitous contaminants produced by natural or anthropogenic processes and found in various environment and food samples. A number of PAHs are carcinogenic and listed as priority pollutants in a variety of regulations. For a long time, much public attention has been drawn on PAHs due to the sensitive issue of environmental risks and food safety. In recent years, immunoassay methods have been applied in environmental and food analysis of PAHs and employed as highly sensitive, selective and cost-effective alternative to complement traditional chromatographic analysis. In this article, the rapid progress in the immunoassays for analysis of PAHs in food and environmental samples, such as selecting haptens, producing antibodies and developing immunoanalytical methods, has been reviewed. Since there was a comprehensive review published in 2002, this article is mainly focusing on the achievements since 2002 in this field. Some significant works before 2002 are also included. Although there have been quite a few antibodies and immunoassays for PAHs available, more novel antibodies and immunoanalytical methods are still welcome. Moreover, class-selective determinations and quantitative structure-activity relationship (QSAR) techniques are likely to play an important role in PAHs immunoassays in the future.
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Cite this article as:
Zhang Yan-Feng*, Gao Zhi-Xian, Antibody Development and Immunoassays for Polycyclic Aromatic Hydrocarbons (PAHs), Current Organic Chemistry 2017; 21 (26) . https://dx.doi.org/10.2174/1385272821666170503104609
DOI https://dx.doi.org/10.2174/1385272821666170503104609 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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